Autoinflammatory & rare systemic diseases
Serum proteomic profiles of patients with chronic recurrent multifocal osteomyelitis
Authors' conclusion
Proteomic analysis identified upregulated proteins in the sera of patients with acute CRMO.
Study context
- Population
- Patients with chronic recurrent multifocal osteomyelitis (CRMO)11 CRMO patients · 4 controls
- Participants
- 5 / 6 / 4
- Comparison
- Active CRMO vs inactive CRMO vs children without inflammatory diseases
- Active CRMOn = 5
- Inactive CRMOn = 6
- Controlsn = 4reference
- Outcome
- Serum proteomic profile
Methodological detailsserum proteomic profiling by liquid chromatography-mass spectrometry, pathway analysis
- Serum proteomic profiling by liquid chromatography-mass spectrometry
- Pathway analysis
Main finding
As reported in the abstract
Proteins upregulated in active CRMO vs controls
19
Proteins downregulated in active CRMO vs controls
41
Proteins upregulated in active vs inactive CRMO, highly enriched in intermediate filament organization
36
Keratin proteins among those upregulated in active vs inactive CRMO
11
Original publication
Serum proteomic profiles of patients with chronic recurrent multifocal osteomyelitis. Rheumatology (Oxford). Published 22 May 2024. doi:10.
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