Systemic sclerosis & Raynaud's
Serum miR-21 and miR-29a expression in systemic sclerosis patients
Authors' conclusion
Our data showed a deregulation of miR-21 and miR-29a in the serum of patients with SSc which could suggests their potential role in the disease pathogenesis.
Study context
- Population
- SSc patients fulfilling the ACR/EULAR 2013 classification criteria, and healthy donors as controls
- Comparison
- Serum miR-21 and miR-29a in SSc patients vs healthy controls
- SScn = 34
- HCsn = 14reference
- Outcome
- Serum expression levels of miR-21 and miR-29a and their correlation with clinical and immunological parameters
Methodological detailscase-control
- Case-control
Performance
As reported in the abstract
Serum miR-21 and miR-29a expression in SSc and diagnostic accuracy (ROC)
| Test or model | AUC | Sensitivity | Specificity | Upregulated in SSc patients | Downregulated in SSc patients |
|---|---|---|---|---|---|
| miR-21 | 0.634 (95% CI=0.479-0.790), p=0.147 | 64.7% | 64.3% | 17 (50.0%) | |
| miR-29a | 0.605 (95% CI=0.420-0.790), p=0.257 | 64.3% | 52.9% | 15 (44.12%) | |
| miR-21 + miR-29a | 0.714 (95% CI=0.569-0.860), p=0.021 | 79.4% | 42.9% |
AUC
miR-210.634 (95% CI=0.479-0.790), p=0.147
miR-29a0.605 (95% CI=0.420-0.790), p=0.257
miR-21 + miR-29a0.714 (95% CI=0.569-0.860), p=0.021
Sensitivity
miR-2164.7%
miR-29a64.3%
miR-21 + miR-29a79.4%
Specificity
miR-2164.3%
miR-29a52.9%
miR-21 + miR-29a42.9%
Upregulated in SSc patients
miR-2117 (50.0%)
miR-29a— not stated in the abstract
miR-21 + miR-29a— not stated in the abstract
Downregulated in SSc patients
miR-21— not stated in the abstract
miR-29a15 (44.12%)
miR-21 + miR-29a— not stated in the abstract
Further findings
Correlation of serum miR-29a with miR-21
- Spearman correlation coefficient, p=0.00017
- 0.517
Correlation of serum miR-29a with presence of anti-Scl70 antibodies
- Spearman correlation coefficient, p=0.010
- 0.438
Original publication
Serum miR-21 and miR-29a expression in systemic sclerosis patients. Clin Exp Rheumatol. Published 22 April 2023. doi:10.
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