Systemic sclerosis & Raynaud's
Could the IgA isotype provide additional information in systemic sclerosis patients? A retrospective study entailing IgA isotyping in a Mediterranean systemic sclerosis cohort
Authors' conclusion
Most of the patients presented ACA, ATA, or RP3 autoantibodies of IgA isotype in addition to IgG.
Study context
- Population
- Mediterranean cohort of patients with SSc fulfilling the 2013 ACR/EULAR classification criteria
- Participants
- 97 vs 50
- Exposure
- SSc vs Blood donors
- SScn = 97
- Blood donorsn = 50reference
- Outcome
- Prevalence of ACA, ATA, RP3 and Ro52 autoantibodies of IgG and IgA isotype and their association with clinical manifestations
Methodological detailsFEIA testing of IgG and IgA isotypes, blood donor controls
- FEIA testing of IgG and IgA isotypes
- Blood donor controls
Main finding
As reported in the abstract
Prevalence of IgG+IgA isotypes for the same specificity
- ACA IgG+IgA
- 62.5%
- ATA IgG+IgA
- 82.6%
- RP3 IgG+IgA
- 80.0%
- Ro52 IgG+IgA
- 36.8%
- Isolated IgG, ACA
- 35.4%
- Isolated IgG, ATA
- 13.0%
- Isolated IgG, RP3
- 20.0%
- Isolated IgG, Ro52
- 42.1%
- Patients isolated IgA for a unique specificity
- 6
Observational data: associations, not effects.
Further findings
Clinical associations
- ILD tended to be associated with ATA-IgG and ATA-IgG+IgA, telangiectasias with ACA-IgG+IgA and arthritis with ACA-IgA
- Digital ulcers more frequent in ATA-IgG patients
Original publication
Could the IgA isotype provide additional information in systemic sclerosis patients? A retrospective study entailing IgA isotyping in a Mediterranean systemic sclerosis cohort. Clin Exp Rheumatol. Published 21 June 2023. doi:10.
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