Serum hepcidin evaluation as a promising biomarker in juvenile idiopathic arthritis
Authors' conclusion
HEP is associated with JIA disease activity, and it could be useful in early detection and monitoring of disease exacerbations.
Study context
- Population
- Non-systemic onset juvenile idiopathic arthritis (JIA) patients, with/without anaemia14 males · 65 females
- Participants
- 79 patients
- Exposure
- Serum hepcidin-25 vs disease activity (JADAS-27), anaemia parameters and iron status in JIA
- Outcome
- Correlation of serum hepcidin-25 (HEP) with disease activity (JADAS-27), anaemia parameters and iron status indices
Main finding
As reported in the abstract
P < 0.0001
- Correlation of serum HEP with JADAS-27 score (r)
- 0.8988
Observational data: associations, not effects.
Further findings
HEP >4.35 ng/mL for discriminating active disease (ROC)
- Sensitivity
- 91.8%
- Specificity
- 80.0%
- AUC
- 0.93 (95% CI 0.88-0.98)
HEP by disease activity level
- Mean serum HEP significantly greater in high disease activity group than in others (p<0.0001)
HEP in anaemic, iron repleted and active disease patients
- HEP significantly higher in anaemic, iron repleted and active disease patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Serum hepcidin evaluation as a promising biomarker in juvenile idiopathic arthritis. Clin Exp Rheumatol. Published 19 January 2024. doi:10.
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