Selective estrogen receptor modulators (SERMs) with vitamin D composite agent can prevent fracture better than SERMs treatment: based on the National Health Claims Database 2017–2019
Main finding · Osteoporotic fractureResult — go to the resultHazard ratio 0.77 95% CI 0.61–0.97Authors' conclusion
The risk of osteoporotic fractures, especially hip fractures, was lower in the SERM + VitD group than in the SERMs group.
Study context
- Population
- Women aged ≥ 50 years with osteoporosis, Korean National Health Insurance Service database 2017–2019propensity score matched
- Participants
- 2,885 vs 2,885
- Exposure
- SERM + vitamin D composite agent vs SERMs only
- SERM + VitDn = 2,885
- SERMsn = 2,885reference
- Outcome
- Osteoporotic fracture (vertebrae, hip, wrist or humerus)
Methodological detailspropensity-score matched, nationwide health claims database, Cox proportional hazards regression
- Propensity-score matched
- Nationwide health claims database
- Cox proportional hazards regression
Main finding
Osteoporotic fracture
Hazard ratio
0.77
95% CI 0.61–0.97
P = 0.024
By group
SERM + VitD
138.6/10,000
incidence rate · person-years
SERMs
192.4/10,000
incidence rate · person-years
SERM + VitDvs SERMs
HR 0.77 (95% CI 0.61–0.97); P = 0.024
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Hip fracture | 0.25 (0.09–0.71) | P = 0.009 | |
| 0.050.21520Hazard ratio (log scale) |
All-cause mortality
- No difference between the groups
Original publication
Selective estrogen receptor modulators (SERMs) with vitamin D composite agent can prevent fracture better than SERMs treatment: based on the National Health Claims Database 2017–2019. Osteoporos Int. Published 19 January 2024. doi:10.
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