Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study
Authors' conclusion
Subjects with VF available for identification on routine CT scans face a substantially increased risk of death.
Study context
- Population
- Men and women aged 50 years or older with routine CT scans in a Danish hospital in 2010 or later, not treated with osteoporosis medications
- Exposure
- Opportunistically identifiable VF on routine CT vs no VF on CT, and vs age- and sex-matched general population
- Outcome
- Death
- Follow-up
- Up to 7 years
Methodological detailsmatched on age and sex (1:2 vs no VF; 1:3 vs general population), blinded two-step VF identification, registry follow-up up to 7 years
- Matched on age and sex (1:2 vs no VF; 1:3 vs general population)
- Blinded two-step VF identification
- Registry follow-up up to 7 years
Main finding
As reported in the abstract
Death during follow-up
Estimate (95% CI)P value
VFvs No VF
aHR 1.51(1.27–1.79)
P < 0.001VFvs General population
HR 4.25(3.53–5.12)
P < 0.001Observational data: associations, not effects.
Further findings
Death, VF vs no VF, by subgroup
- Risk higher in those with moderate or severe VF, no malignancy prior to baseline, and lower Charlson comorbidity index score
Original publication
Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study. Osteoporos Int. Published 18 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →