Sarcopenia assessed by DXA and hand-grip dynamometer: a potential marker of damage, disability and myokines imbalance in inflammatory myopathies
Authors' conclusion
DXA and hand-grip dynamometer are useful tools to assess damage in IM.
Study context
- Population
- Adults with inflammatory myopathies (IM), disease duration ≥12 months, low or no disease activity for ≥6 months
- Participants
- 40 vs 30
- Comparison
- IM patients vs healthy volunteers
- IMn = 40
- Volunteersn = 30reference
- Outcome
- Ability of DXA and hand-grip dynamometer to measure damage in IM
Methodological detailsage and sex-matched controls
- Age and sex-matched controls
Main finding
As reported in the abstract
Muscle mass decreased in IM vs volunteers (IQR −24.3% to +7.8%)
−10%
Grip strength decreased in IM vs volunteers (IQR −51.3% to −18.9%)
−30%
DXA and grip strength measurements duration
≤20 min
Observational data: associations, not effects.
Further findings
- Sarcopenia (EWGSOP2) in IM
- 17.5% · 7 of 40
Sarcopenia (EWGSOP2) in IM
- Sarcopenic patients had the worst damage, impaired functions, disability and history of severe myopathy
Myokines associated with sarcopenia
- Decreased irisin, AUC
- 0.71
- Decreased osteonectin, AUC
- 0.80
Original publication
Sarcopenia assessed by DXA and hand-grip dynamometer: a potential marker of damage, disability and myokines imbalance in inflammatory myopathies. Rheumatology (Oxford). Published 27 March 2024. doi:10.
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