Risk of non-thyroidal autoimmune diseases in patients with Graves’ disease: a nationwide retrospective cohort study
Authors' conclusion
This study demonstrated an increased risk of SLE, vitiligo and alopecia areata in patients with GD. In the GD cohort, patients with GO had an increased risk of SLE, SS and AS.
Study context
- Population
- Patients with graves' disease (GD) and age- and sex-matched controls, Korean National Health Claims databasemean follow-up 9 years
- Exposure
- Graves' disease vs age- and sex-matched controls; Graves' ophthalmopathy (GO) vs non-GO within GD
- GDn = 77,401
- Controln = 77,401reference
- GOn = 2,310
- Outcome
- Risk of non-thyroidal autoimmune disease (NTAD)
Methodological detailsnationwide, age- and sex-matched controls
- Nationwide
- Age- and sex-matched controls
Main finding
As reported in the abstract
NTAD risk, GD vs controls · mean follow-up 9 years
GD
16.1%
12 341
GD vs ControlAdjusted hazard ratio (95% CI)
SLE
1.15(1.02–1.29)
Vitiligo
1.24(1.10–1.40)
Alopecia areata
1.11(1.04–1.20)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| NTAD risk within GD cohort, GO vs non-GOGOvs Non-GOSLE | 1.60 (1.11–2.33) | |
| NTAD risk within GD cohort, GO vs non-GOGOvs Non-GOSS | 1.89 (1.30–2.74) | |
| NTAD risk within GD cohort, GO vs non-GOGOvs Non-GOAS | 1.53 (1.08–2.17) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Risk of non-thyroidal autoimmune diseases in patients with Graves’ disease: a nationwide retrospective cohort study. Rheumatology (Oxford). Published 5 January 2024. doi:10.
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