Vasculitis & polymyalgia rheumatica
Risk of Hypertensive Disorders and Preterm Birth in Pregnant Women With Systemic Vasculitides: A Nationwide Population‐Based Cohort Study
Authors' conclusion
About one of seven pregnancies in women with SVs is associated with hypertensive disorders or preterm birth. The occurrence of vasculitides flare was associated with these complications.
Study context
- Population
- All pregnancies between 2013 and 2018 in women with systemic vasculitides (SVs), France, matched to pregnancies in women without SVsfrom 3,155,723 pregnancies
- Participants
- 646 vs 3,230
- Exposure
- Pregnancies in women with SVs vs matched pregnancies in women without SVs
- SVsn = 646
- Controlsn = 3,230reference
- Outcome
- Hypertensive disorders and preterm birth (PTB) during pregnancy
Methodological detailsmatched, nested case-control design for risk factors, French health insurance data warehouse
- Matched
- Nested case-control design for risk factors
- French health insurance data warehouse
Main finding
As reported in the abstract
Each group vs controlsEstimate (95% CI)
SVs
OR (hypertensive disorders) 1.7(1.3–2.2)
SVs
OR (PTB) 1.8(1.4–2.3)
Observational data: associations, not effects.
Further findings
Risk factors for hypertensive disorders (nested case-control)
- Chronic renal failure before pregnancy, history of or treated arterial hypertension, vasculitis flare during pregnancy and SV subgroup independently associated with hypertensive disorders
Risk factors for preterm birth (PTB) (nested case-control)
- Maternal age at delivery, chronic renal failure before conception and vasculitis flare during pregnancy independently associated with PTB
Original publication
Risk of Hypertensive Disorders and Preterm Birth in Pregnant Women With Systemic Vasculitides: A Nationwide Population‐Based Cohort Study. Arthritis Rheumatol. Published 19 January 2024. doi:10.
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