Risk of cardiovascular comorbidities before and after the onset of rheumatic diseases
Authors' conclusion
The risk of CV comorbidities was elevated in all studied rheumatic diseases, with highest risks observed in SLE and gout. The risk for CV diseases was highest immediately before and/or after rheumatic disease diagnosis
Study context
- Population
- FinnGen study patients diagnosed 2000–2014 with rheumatic diseases, identified from healthcare registries1:20 matched controls
- Exposure
- Patients with rheumatic diseases vs matched controls without rheumatic conditions
- Seropositive rheumatoid arthritis (RA)n = 2,368
- Seronegative RAn = 916
- Ankylosing spondylitis (AS)n = 715
- Psoriatic arthritis (PsA)n = 923
- Systemic lupus erythematosus (SLE)n = 190
- Primary Sjogren's syndrome (pSS)n = 412
- Goutn = 2,034
- Outcome
- Prevalence of seven CV diseases (overall RR vs controls)
Methodological detailsregistry-based, matched 1:20 on age, sex and birth region, logistic regression
- Registry-based
- Matched 1:20 on age, sex and birth region
- Logistic regression
Main finding
As reported in the abstract
Any CVD, RR vs controls
Each group vs controlsRelative risk (95 % CI)
PsAlowest RR
1.14(1.02–1.26)
SLEhighest RR
2.05(1.67–2.52)
Observational data: associations, not effects.
Further findings
Timing of cardiovascular (CV) comorbidities relative to rheumatic disease onset (OR)
- ORs highest within one year before and/or after onset of the rheumatic disease
- In gout, excess CV risk especially high before gout diagnosis
Original publication
Risk of cardiovascular comorbidities before and after the onset of rheumatic diseases. Semin Arthritis Rheum. Published 26 January 2024. doi:10.
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