Causal association of leisure sedentary behavior with arthritis: A Mendelian randomization analysis
Authors' conclusion
This study demonstrated the genetic causal association of prolonged TV watching time with overall OA and KOA risks.
Study context
- Population
- Genome-wide association studies (GWAS) data of leisure sedentary behavior (LSB) from UK Biobank; GWAS data of OA (overall, hip, knee), rheumatoid arthritis (RA) (overall, seronegative, seropositive) and psoriatic arthritis (PsA) from FinnGen
- Comparison
- Genetically predicted leisure sedentary behaviour (TV watching, computer use, driving) and risk of OA, RA and PsA
- Outcome
- Risk of common types of arthritis (OA, RA, PsA)
Methodological detailstwo-sample, univariable Mendelian randomization (MR), multivariable MR, CAUSE
- Two-sample
- Univariable MR
- Multivariable MR
- CAUSE
Main finding
As reported in the abstract
Time spent watching TV and OA (UVMR)
TV watching – overall OA, OR
1.80 (1.45-2.23) (95% CI)
TV watching – knee OA, OR
1.86 (1.45-2.39) (95% CI)
TV watching – hip OA, OR (95% CI), IVW-fixed
1.65
1.20–2.26
Further findings
TV watching and overall RA, seropositive RA and PsA (univariable MR (UVMR))
- Similar associations observed; not supported by CAUSE
TV watching and OA (overall, knee, hip) (multivariable MR (MVMR))
- Independent causal effect of TV watching on OA
Original publication
Causal association of leisure sedentary behavior with arthritis: A Mendelian randomization analysis. Semin Arthritis Rheum. Published 28 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →