Lupus & antiphospholipid syndrome

Risk factors of first thrombosis in obstetric antiphospholipid syndrome

Lupus Sci MedPublished Cohort study

Authors' conclusion

Triple-positive aPLs and hypocomplementemia are risk factors for the first thrombosis in patients with OAPS.

Study context

Population
Patients with isolated obstetric antiphospholipid syndrome (OAPS)mean 5.4-year follow-up
Participants
186 patients
Outcome
First thrombosis during or after delivery
Methodological detailsmultivariate binary logistic regression
  • Multivariate binary logistic regression

Main finding

As reported in the abstract

First thrombosis · mean 5.4-year follow-up
Adjusted for low-dose aspirin and HCQ
Odds ratio (95% CI)P value
Triple-positive aPL
11.662(2.117–64.243)
P = 0.005
Hypocomplementemia
9.047(1.530–53.495)
P = 0.015
Patients with thrombotic events
11 (5.9%)

Observational data: associations, not effects.

Original publication

Risk factors of first thrombosis in obstetric antiphospholipid syndrome. Lupus Sci Med. Published 3 January 2024. doi:10.1136/lupus-2023-001044

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