Risk factors for haemodynamic compromise in multisystem inflammatory syndrome in children: a multicentre retrospective study
Authors' conclusion
Key clinical and laboratory parameters of MIS-C were identified as risk factors for severe disease, predominantly during the disease course and not at the time of admission
Study context
- Population
- Children with multisystem inflammatory syndrome in children (MIS-C) (CDC definition) in nine Israeli and one US medical centre, July 2020–March 202161 (61%) male
- Participants
- 100 children
- Outcome
- Severe disease, defined by need for inotropic support
Methodological detailsmulticentre, univariate and multivariate regression
- Multicentre
- Univariate and multivariate regression
Main finding
As reported in the abstract
Predictors of severe disease (inotropic support)
- Required inotropic support
- 44
- LV dysfunction, univariate OR
- 4.178 (95% CI 1.760, 9.917)
- Conjunctivitis at admission, univariate OR
- 0.403 (95% CI 0.173, 0.938)
- Mucosal changes at admission, univariate OR
- 0.333 (95% CI 0.119, 0.931)
- Multivariate: mucosal involvement, fold lower risk of severe disease
- 6.2
Observational data: associations, not effects.
Original publication
Risk factors for haemodynamic compromise in multisystem inflammatory syndrome in children: a multicentre retrospective study. Rheumatology (Oxford). Published 30 December 2022. doi:10.
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