Spondyloarthritis & psoriatic arthritis
Risk of cancer, tuberculosis and serious infections in patients with ankylosing spondylitis, psoriatic arthritis and psoriasis treated with IL-17 and tumour necrosis factor (TNF)-α inhibitors: a nationwide nested case-control analysis
Authors' conclusion
In this nationwide cohort of IL-17 and TNF-α inhibitor users, both treatments conferred comparable risk of cancer and serious infections, while IL-17 inhibitors may be advantageous for TB.
Study context
- Population
- Patients newly diagnosed with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and psoriasis between 2010–2020, Health Insurance Review and Assessment Service databasethree datasets
- Participants
- 40,322 / 4,953 / 5,347
- Comparison
- IL-17 inhibitors vs TNF-α inhibitors
- ASn = 40,322
- PsAn = 4,953
- Psoriasis (PsO)n = 5,347
- Outcome
- Cancer, TB and serious infections following IL-17 and TNF-α inhibitor use
Methodological detailsnationwide, matched (maximum 1:10) on index age, sex, index year and follow-up duration, conditional logistic regression
- Nationwide
- Matched (maximum 1:10) on index age, sex, index year and follow-up duration
- Conditional logistic regression
Main finding
As reported in the abstract
Associations with cancer, TB and serious infections
- Cyclosporine use, cancer (OR)
- 2.286 (p=0.0176)
- Higher Charlson Comorbidity Index (CCI) score, tuberculosis (TB) (OR)
- 1.085 (p=0.0406)
- IL-17 inhibitor use only, TB (OR)
- 0.126 (p=0.0457)
- High CCI scores, serious infections (OR)
- 1.117 (p<0.0001)
- Cyclosporine use, serious infections (OR)
- 1.445 (p=0.0098)
- Medical-aided individuals, serious infections (OR)
- 1.667 (p<0.0001)
Observational data: associations, not effects.
Original publication
Risk of cancer, tuberculosis and serious infections in patients with ankylosing spondylitis, psoriatic arthritis and psoriasis treated with IL-17 and TNF-α inhibitors: a nationwide nested case-control analysis. Clin Exp Rheumatol. Published 29 August 2022. doi:10.
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