Rheumatoid arthritis disease activity significantly impacts on the severity of interstitial lung disease
Authors' conclusion
Disease activity of RA was significantly associated with the severity of RA-ILD both radiologically and physiologically.
Study context
- Population
- Consecutive patients with rheumatoid arthritis (RA) at a Rheumatology Centre, December 2020 to December 2023 (median age 70 years; median disease duration 2.92 years)32 men · 92 women
- Participants
- 124 patients
- Outcome
- Radiological severity of ILD (Goh and Walsh HRCT extent) and physiological severity, associations with patients' features
Methodological detailsconsecutive patients, single-centre, multivariate linear regression
- Consecutive patients
- Single-centre
- Multivariate linear regression
Main finding
As reported in the abstract
Association with radiological quantitative severity of ILD (multivariate, adjusted for age, sex, disease duration, smoking status and ACPA titre)
DAS28-ESR, standardized coefficient (P = 0.03)
0.199
RF titre, standardized coefficient (P = 0.01)
0.247
Observational data: associations, not effects.
Further findings
Distribution of radiological interstitial lung disease (ILD) severity
- 0% (without ILD): 107
- 86.2%
- ILD extent < 10%: 9
- 7.2%
- ILD extent ≥10% and < 20%: 3
- 2.4%
- ILD extent ≥20%: 5
- 4.0%
Association of DAS28-ESR with FVC% predicted
- Standardized coefficient (P = 0.047)
- −0.230
Original publication
Rheumatoid arthritis disease activity significantly impacts on the severity of interstitial lung disease. Arthritis Res Ther. Published 4 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →