Rheumatoid arthritis-associated interstitial lung disease in countries across the world
Authors' conclusion
Despite slight differences in RA-ILD prevalence and incidence between countries, the incidence of RA-ILD in daily practice is low in our RA population from different continents. Patients with RA-ILD had a higher disease activity than patients without RA-ILD, and were more often ACPA positive and/or (former) smokers.
Study context
- Population
- Patients with RA with variable disease duration in 5 countries (METEOR, EAC databases); RA-ILD clinically diagnosed on chest X-ray or CT
- Participants
- 16,663 patients5 countries
- Exposure
- RA-ILD vs RA without ILD for disease activity
- Netherlandsn = 1,077
- Indian = 11,787
- South African = 629
- Mexicon = 424
- Colombian = 2,728
- Outcome
- Incidence of RA-ILD
Methodological detailstwo observational databases (METEOR, EAC), 5 countries
- Two observational databases (METEOR, EAC)
- 5 countries
Main finding
As reported in the abstract
Incidence rate of RA-ILD in newly diagnosed RA, per 1000 patient years
Observational data: associations, not effects.
Further findings
| Outcome | Values | OR (95 % CI) | |
|---|---|---|---|
| RA-ILD development per point increase in DAS28 over time | 1.19 (0.34–4.22) | ||
| 0.20.5125Odds ratio (log scale) |
| Outcome | Values | β (95 % CI) |
|---|---|---|
| RA-ILD diagnosis at first visit (prevalence) · first visit recorded in the database | Netherlands 0.09 % · India 0.53 % · South Africa 1.27 % · Mexico 1.42 % · Colombia 0.62 % | |
| Disease activity after RA-ILD diagnosis or matched timepointRA-ILD vs controls | 0.56 (0.18–0.93) |
DMARD use
- There were no clear differences in DMARD use between the two groups
Original publication
Rheumatoid arthritis-associated interstitial lung disease in countries across the world. Semin Arthritis Rheum. Published 12 April 2025. doi:10.
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