Rheumatoid arthritis and the risk of major cardiometabolic diseases: a Mendelian randomization study
Authors' conclusion
Genetically determined RA was associated with increased risks of T2D and CAD
Study context
- Population
- European subjects; Genome-wide association study (GWAS) of rheumatoid arthritis (RA) (58,284) and three GWASs of T2D, coronary artery disease (CAD) and ischaemic stroke
- Participants
- 1,529,131 outcome GWASs
- Comparison
- Genetically determined RA and risk of T2D, CAD and ischaemic stroke
- Outcome
- Cardiometabolic diseases per genetically determined RA (IVW MR)
Methodological detailstwo-sample summary-level GWAS data, inverse-variance weighted (IVW) Mendelian randomization (MR) main analysis, sensitivity analyses: multiple MR methods, MR-Egger, leave-one-out
- Two-sample summary-level GWAS data
- Inverse-variance weighted (IVW) MR main analysis
- Sensitivity analyses: multiple MR methods, MR-Egger, leave-one-out
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
Genetically determined RA: T2D
1.04(1.02–1.05)
P < 0.001Genetically determined RA: CAD
1.02(1.00–1.03)
P = 0.012Genetically determined RA: ischaemic stroke
1.00(0.99–1.02)
P = 0.961Per genetically determined RA, as printed
Further findings
Sensitivity analyses
- Multiple MR methods confirmed the associations
- MR-Egger: no evidence of pleiotropy
- Leave-one-out: associations not driven by any individual SNP
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Rheumatoid arthritis and the risk of major cardiometabolic diseases: a Mendelian randomization study. Scand J Rheumatol. Published 6 June 2022. doi:10.
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