Rheumatoid Arthritis and Risk of Thyroid Cancer: A Nationwide Cohort Study
Main finding · Thyroid cancerResult — go to the resultAdjusted hazard ratio 0.98 95% CI 0.85–1.13Authors' conclusion
Patients with newly diagnosed RA did not show a different risk of thyroid cancer compared to a matched control group. The risk of thyroid cancer incidence was not affected by serologic status of RA, sex, or age.
Study context
- Population
- Patients with newly diagnosed rheumatoid arthritis (RA) (2010–2017) in a nationwide database and sex- and age-matched controls without RA1:5 matched cohort
- Exposure
- Newly diagnosed RA vs matched individuals without RA
- RAn = 40,895
- Controln = 204,475reference
- Outcome
- Thyroid cancer
- Follow-up
- 5.5 years
Methodological detailsnationwide database, matched by sex and age at a 1:5 ratio, Cox regression
- Nationwide database
- Matched by sex and age at a 1:5 ratio
- Cox regression
Main finding
As reported in the abstract
Adjusted hazard ratio
0.98
95% CI 0.85–1.13
RAvs Control
aHR 0.98 (95% CI 0.85–1.13)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Thyroid cancer by RA serostatusSeropositive RAvs Seronegative RA | 1.03 (0.78–1.36) | |
| 0.512Adjusted hazard ratio (log scale) |
Thyroid cancer stratified by age or sex
- No statistical interaction
Original publication
Rheumatoid Arthritis and Risk of Thyroid Cancer: A Nationwide Cohort Study. Arthritis Care Res (Hoboken). Published 11 August 2025. doi:10.
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