Rheumatoid arthritis and interstitial lung disease: the role of comorbidities—a retrospective analysis of two RA inception cohorts in the UK
Authors' conclusion
The method chosen to assess the comorbidity burden affected whether baseline comorbidity was associated with subsequent ILD development.
Study context
- Population
- Patients with RA from two RA inception cohorts in the UKmedian follow-up 6 years
- Participants
- 2,701 patients
- Exposure
- Comorbidity burden and clinical factors vs development of interstitial lung disease (ILD)
- Outcome
- ILD diagnosis
Methodological detailstwo consecutive multicentre, prospective RA inception cohorts, multivariable logistic regression
- Two consecutive multicentre, prospective RA inception cohorts
- Multivariable logistic regression
Main finding
As reported in the abstract
Associations with ILD diagnosis (multivariable)
Adjusted odds ratio (95% CI)
Lung disease component of RDCI (higher burden)
4.59(2.68–7.88)
Entire RDCI
1.32(1.07–1.63)
Age at onset
1.03(1.01–1.05)
Seropositivity
2.58(1.38–4.81)
Ever smoking
1.70(1.04–2.79)
Observational data: associations, not effects.
Further findings
ILD incidence
- Patients diagnosed with ILD
- 101 (3.7%)
- Diagnosis at baseline
- 12 (0.44%)
- Diagnosed during follow-up
- 46
- Identified from death certificates
- 43
Original publication
Rheumatoid arthritis and interstitial lung disease: the role of comorbidities—a retrospective analysis of two RA inception cohorts in the UK. Rheumatology (Oxford). Published 16 February 2026. doi:10.
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