Higher comorbidities associated with less improvement in disease activity in early RA: results from CATCH cohort
Authors' conclusion
This large real-world analysis of ERA patients seen in routine rheumatology practice across Canada showed that while RA disease activity across comorbidity groups at diagnosis was similar, higher comorbidity was associated with slower improvement in RA disease activity over the first year of treatment, likely driven by independent associations with patient and physician global assessments and pain.
Study context
- Population
- Participants with early RA enrolled in the Canadian Early Arthritis Cohort (CATCH), first year of treatment
- Participants
- 2,248 participants
- Exposure
- Rheumatic Disease Comorbidity Index (RDCI) scores 0, 1, 2 and ≥3
- Outcome
- Trajectories of SDAI and its components
- Follow-up
- First year of treatment
Methodological detailsmultivariable generalized estimating equations, adjusted for multiple confounders, real-world
- Multivariable generalized estimating equations
- Adjusted for multiple confounders
- Real-world
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
SDAI components (pain, patient and physician global assessments) over time
- Higher RDCI scores independently associated with pain, patient and physician global assessments over time
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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