Results of a Nationwide Multicenter Study in Childhood Sjögren Disease
Authors' conclusion
The current classification criteria for childhood SjD appear to be inadequate, highlighting the need for pediatric-specific criteria that more accurately reflect the distinct clinical patterns observed in children.
Study context
- Population
- Patients <18 years with primary Sjögren disease (SjD) in childhood, 21 pediatric rheumatology centres85.2% female
- Participants
- 81 patients
- Exposure
- Childhood SjD meeting 2016 American College of Rheumatology (ACR)/EULAR criteria vs at risk for childhood SjD
- Childhood SjDn = 51reference
- At riskn = 30
- Outcome
- Demographic and clinical features
Methodological detailsmulticentre, nationwide
- Multicentre
- Nationwide
Main finding
As reported in the abstract
Median age at symptom onset
11.4 years
Median follow-up
24 months
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Dry mouth and peripheral nervous system involvementAt risk vs Childhood SjD · dry mouth higher in at risk | P = 0.03 |
| Dry mouth and peripheral nervous system involvementAt risk vs Childhood SjD · peripheral nervous system involvement higher in at risk | P = 0.02 |
Most common clinical findings in the at-risk group
- Xerostomia
- 90%
- Arthralgia
- 56.7%
- Fatigue
- 50%
- Dry eyes
- 43.3%
Original publication
Results of a Nationwide Multicenter Study in Childhood Sjögren Disease. J Rheumatol. Published 15 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →