Spondyloarthritis & psoriatic arthritis
Repair of radiographic joint damage in psoriatic arthritis: a cohort study
Authors' conclusion
Radiographic improvement consistent with damage repair is not infrequent in PsA. Concomitant treatment with biologic DMARDs and MTX is a predictor of slower radiographic progression and damage repair.
Study context
- Population
- Patients with psoriatic arthritis (PsA) (54.7% male), mean age 44.4 years (SD 12.8), mean disease duration 6.3 years (SD 8.0) at clinic entry
- Participants
- 674 patients7189.5 person-years
- Outcome
- Damage repair (decrease in joint-level mSS) of hands and feet: frequency and predictors
Methodological detailsbiennial radiographic assessments, multistate Markov models
- Biennial radiographic assessments
- Multistate Markov models
Main finding
As reported in the abstract
Damage repair (decrease in joint-level mSS)
Patients developing at least one damaged joint (modified Steinbrocker score (mSS) ≥2)
428
63.4%
Of these, repair in at least one joint
127
29.7%
Joints with radiographic improvement
361
Observational data: associations, not effects.
Further findings
Progression rate for joint damage
| RR (95% CI) | ||
|---|---|---|
| Combination of methotrexate and biologic DMARDs | 0.48 (0.38–0.62) | |
| 0.20.5125Relative risk (log scale) |
Rate of damage repair
| RR (95% CI) | ||
|---|---|---|
| Combination of methotrexate and biologic DMARDs | 1.97 (1.13–3.45) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Repair of radiographic joint damage in psoriatic arthritis: a cohort study. Rheumatology (Oxford). Published 19 May 2026. doi:10.
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