Reliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition: Performance of the Novel Definitions Developed by an International Multidisciplinary Working Group
Authors' conclusion
The new radiographic definitions of CPPD are highly specific against the gold standard of histologic diagnosis.
Study context
- Population
- Patients with knee OA scheduled for knee replacement51 in accuracy study
- Participants
- 67 patients
- Comparison
- Radiography using new CPPD definitions vs histology under compensated polarized light microscopy
- Outcome
- Reliability (prevalence-adjusted bias-adjusted kappa) and diagnostic accuracy of new radiographic CPPD definitions
Methodological detailsreliability study, histologic reference standard, 2 radiologists and 2 rheumatologists twice assessed radiographs
- Reliability study
- Histologic reference standard
- 2 radiologists and 2 rheumatologists twice assessed radiographs
Performance
As reported in the abstract
Diagnostic accuracy for CPPD (overall)
| Test or model | Specificity | Sensitivity |
|---|---|---|
| Radiography | 92% | 54% |
Radiography
Specificity92%
Sensitivity54%
Further findings
Interobserver reliability, all 4 readers
- Substantial in most structures (κ range)
- 0.59-0.90
Interobserver reliability, radiologists
- Substantial to almost perfect (κ range)
- 0.70-0.91
Interobserver reliability, rheumatologists
- Moderate to almost perfect (κ range)
- 0.46-0.88
Intraobserver reliability, all observers
- Substantial to almost perfect (κ range)
- 0.70-1
Original publication
Reliability and Diagnostic Accuracy of Radiography for the Diagnosis of Calcium Pyrophosphate Deposition: Performance of the Novel Definitions Developed by an International Multidisciplinary Working Group. Arthritis Rheumatol. Published 19 January 2023. doi:10.
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