Relationship of regional ultraviolet index data with rash and systemic disease activity in youth with childhood-onset systemic lupus: results from the Childhood Arthritis and Rheumatology Research Alliance Registry
Authors' conclusion
This study found no association between UVI and rash or UVI and disease activity.
Study context
- Population
- Youth with childhood-onset SLE (cSLE) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry with visits between 2010 and 2019mean 2.3 visits per participant
- Participants
- 1,222 participants
- Exposure
- Regional UVI and season during the month of visit and one month prior
- Outcome
- Odds of rash and of severe SLEDAI-2K score (≥ 5 vs. 0-4)
Methodological detailsregistry-based, mixed-effects logistic regression, adjusted for age, sex, race and income
- Registry-based
- Mixed-effects logistic regression
- Adjusted for age, sex, race and income
Main finding
As reported in the abstract
Association of UVI with rash and systemic disease activity
- No associations between UVI during the month prior to visit or the month of visit and odds of rash or elevated systemic activity
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Fall season and rashNot associated with increased disease activity | 1.59 | P = 0.04 |
Visits with rash
- Visits with rash
- 437 visits (15%)
- Visits with SLEDAI-2K score ≥ 5
- 860 (30%)
Original publication
Relationship of regional ultraviolet index data with rash and systemic disease activity in youth with childhood-onset systemic lupus: results from the Childhood Arthritis and Rheumatology Research Alliance Registry. Pediatr Rheumatol Online J. Published 15 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →