Reduction of Proinflammatory Effector Functions Through Remodeling of Fatty Acid Metabolism in CD8 + T Cells From Rheumatoid Arthritis Patients
Authors' conclusion
RA CD8+ T cells present an altered FA metabolism, which could provide potential therapeutic targets to control their proinflammatory profile, particularly therapies directed against the transport and oxidation of free FA.
Study context
- Population
- Peripheral blood CD8+ T cells from patients with rheumatoid arthritis (RA), PsA and SpA and from healthy controls; GEO transcriptomic data of RA patients and healthy controls
- Participants
- 31 / 26 / 21 / 14
- Comparison
- RA CD8+ T cells vs healthy controls, with or without fatty acid (FA) metabolism inhibitors
- RAn = 31
- Psoriatic arthritisn = 26
- Spondyloarthritisn = 21
- Healthy controlsn = 14reference
Methodological detailstranscriptomic analysis of GEO database data, in vitro functional assays
- Transcriptomic analysis of GEO database data
- In vitro functional assays
Main finding
As reported in the abstract
- CD8+ T cell expression profile of FA metabolism-related genes significantly different between untreated RA patients and healthy controls
- Good clinical responders after 6 months of MTX had significantly increased expression of FA metabolism-related genes
- Cell surface FABP4 and GPR84 and FA uptake higher in effector and memory CD8+ T cells from RA patients vs healthy controls
- In vitro blockade of FA metabolism significantly impaired CD8+ T cell effector functions
Original publication
Reduction of Proinflammatory Effector Functions Through Remodeling of Fatty Acid Metabolism in CD8 + T Cells From Rheumatoid Arthritis Patients. Arthritis Rheumatol. Published 13 April 2023. doi:10.
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