Reduction of non-classical monocytes that suppress interferon-α in patients with systemic lupus erythematosus
Authors' conclusion
Our study demonstrated that the number of circulating non-classical monocytes, which has been shown to have the ability to suppress IFN-α production, was decreased in SLE patients, and this might be related to the excess IFN signature in SLE patients.
Study context
- Population
- Patients with autoimmune diseases (systemic lupus erythematosus (SLE), RA, SSc) and healthy donors; peripheral blood monocyte subsets
- Participants
- 53 / 12 / 36 / 28
- Comparison
- SLE vs healthy donors and patients with other autoimmune diseases
- SLEn = 53
- RAn = 12
- SScn = 36
- Healthy donorsn = 28reference
- Outcome
- Circulating CD14dimCD16+ non-classical monocytes
Methodological detailsflow cytometry, in vitro functional assay
- Flow cytometry
- In vitro functional assay
Main finding
As reported in the abstract
- Number of non-classical monocytes significantly decreased in SLE vs healthy donors and patients with other autoimmune diseases
- Number of non-classical monocytes inversely correlated with SLE disease activity
- Number not related to GC use or to presence or absence of specific tissue inflammation
- Cell surface molecule expression and survival rate of non-classical monocytes in SLE similar to healthy donors
- In vitro, non-classical monocytes suppressed IFN-α production from PBMCs or plasmacytoid DCs; cell-cell contact through ICAM-4 seemed important
Original publication
Reduction of non-classical monocytes that suppress interferon-α in patients with systemic lupus erythematosus. Clin Exp Rheumatol. Published 13 November 2024. doi:10.
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