Sjögren's disease & overlap diseases
Real-world damage accrual in Sjögren’s disease: a 5-year multicentre GIRRCS cohort analysis
Authors' conclusion
Irreversible damage in SD occurs early, often present at diagnosis and affects multiple organ domains.
Study context
- Population
- Adult patients with SjD from the GIRRCS network with ≥1 year of follow-up
- Participants
- 429 patients
- Outcome
- Irreversible damage (SSDI) across ocular, oral and systemic domains
- Follow-up
- 5 years
Methodological detailsmulticentre, Cox proportional hazards models, Kaplan-Meier curves, exploratory Least Absolute Shrinkage and Selection Operator (LASSO) and principal component analysis (PCA) analyses
- Multicentre
- Cox proportional hazards models
- Kaplan-Meier curves
- Exploratory LASSO and PCA analyses
Main finding
As reported in the abstract
Cumulative damage · After 5 years
Cumulative damage
65%
Ocular
34.2%
Oral
21.7%
Systemic
40.8%
Observational data: associations, not effects.
Further findings
Damage at baseline (Sjögren's Syndrome Damage Index (SSDI)≥1)
- SSDI≥1
- 48%
- Ocular
- 25.4%
- Systemic
- 22.5%
- Oral
- 14.3%
Predictors of damage
- Higher baseline ESSDAI predicted damage across all domains
- Elevated EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) associated with oral damage
- Abnormal Schirmer's test strongly predicted ocular damage
- Anti-Ro/La antibodies, elevated C reactive protein (CRP) and recurrent oral infections linked to higher domain-specific damage
- Glandular, peripheral nervous system and pulmonary ESSDAI domains independently contributed to systemic damage (LASSO)
- Patient-reported symptoms and systemic activity are complementary, independent dimensions (PCA)
Original publication
Real-world damage accrual in Sjögren’s disease: a 5-year multicentre GIRRCS cohort analysis. RMD Open. Published 21 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →