Spondyloarthritis & psoriatic arthritis
Psoriatic arthritis phenotype may vary depending on whether the skin or joint domain appears first or whether both appear simultaneously
Authors' conclusion
In this study, substantial phenotypic differences were identified based on the three PsA lag time models.
Study context
- Population
- Psoriatic arthritis (PsA) patients classified by psoriasis-arthritis lag time
- Participants
- 340 patients
- Exposure
- Simultaneous onset vs psoriasis first vs arthritis first
- Sn = 45
- Psoriasis first (PF)n = 198
- Arthritis first (AF)n = 97
- Outcome
- PsA phenotypic features by psoriasis-arthritis lag-time model
Methodological detailsBenjamini-Hochberg post-hoc correction of significant p-values
- Benjamini-Hochberg post-hoc correction of significant p-values
Main finding
As reported in the abstract
| Group | Value | Dactylitis during follow-up | HLA-Cw6 positivity | Nail psoriasis | Scalp psoriasis | Fold psoriasis | ≥3 psoriasis body areas | Psoriasis family history |
|---|---|---|---|---|---|---|---|---|
| S | 13.2% | 44% | ||||||
| PF | 58.2% | 43.2% | ||||||
| AF | 28.5% | 18.8% | 28.1% | 10.9% | 18.8% | 67.6% |
Value
S13.2%
PF58.2%
AF28.5%
Dactylitis during follow-up
S44%
PF— not stated in the abstract
AF— not stated in the abstract
HLA-Cw6 positivity
S— not stated in the abstract
PF43.2%
AF— not stated in the abstract
Nail psoriasis
S— not stated in the abstract
PF— not stated in the abstract
AF18.8%
Scalp psoriasis
S— not stated in the abstract
PF— not stated in the abstract
AF28.1%
Fold psoriasis
S— not stated in the abstract
PF— not stated in the abstract
AF10.9%
≥3 psoriasis body areas
S— not stated in the abstract
PF— not stated in the abstract
AF18.8%
Psoriasis family history
S— not stated in the abstract
PF— not stated in the abstract
AF67.6%
- AF less frequently nail psoriasis
- P < 0.001
- AF less frequently scalp psoriasis
- P = 0.001
- AF less frequently fold psoriasis
- P = 0.009
- AF less frequently ≥3 psoriasis body areas
- P < 0.001
- AF more psoriasis family history
- P = 0.001
- S more dactylitis during follow-up
- P = 0.012
- PF younger at psoriasis onset
- P < 0.001
- PF more extensive psoriasis
- P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | PF | AF | P value |
|---|---|---|---|
| Psoriasis-arthritis lag timePF vs AF | 16.3 ± 12.4 years | 5.4 ± 2.8 years | P < 0.001 |
- Psoriasis-arthritis latency within PF: axial onset vs other onset forms (subgroup): Axial onset median 19.0 (IQR 10.5–25.5) years
- Psoriasis-arthritis latency within PF: axial onset vs other onset forms (subgroup): Other onset forms median 14.0 (IQR 5–24) years
Original publication
Psoriatic arthritis phenotype may vary depending on whether the skin or joint domain appears first or whether both appear simultaneously. Clin Exp Rheumatol. Published 9 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →