Spondyloarthritis & psoriatic arthritis
Psoriatic arthritis: improvement in outcomes but persistent sex difference – 5-year follow-up study of a Norwegian outpatient clinic population
Authors' conclusion
This study adds evidence supporting recent improvements in PsA outcomes. Women had higher disease activity and were less likely to achieve remission than men.
Study context
- Population
- Psoriatic arthritis (PsA) patients treated in a Norwegian outpatient clinic
- Participants
- 114 patients
- Exposure
- Baseline vs 5-year follow-up; women vs men
- Outcome
- Long-term changes in disease activity and remission rates, and sex-related differences in these outcomes
- Follow-up
- 5 years
Methodological detailsoutpatient clinic, 5-year follow-up
- Outpatient clinic
- 5-year follow-up
Main finding
As reported in the abstract
Remission by Disease Activity Score (DAS28) (statistically significant increase)
+21.2%
Remission by CDAI (statistically significant increase)
+9.7%
Remission by clinical DAPSA (cDAPSA) (statistically significant increase)
+7.6%
Observational data: associations, not effects.
Further findings
Treated with bDMARDs, by sex · value = baseline
Follow-up
Patients treated with biological disease-modifying anti-rheumatic drugs (bDMARDs), baseline to follow-up · 5 years
- Increase from 37.7% to 48.3%
- P = 0.007
Sex differences in disease activity and remission · mean baseline
- Women reported higher pain and fatigue, and had higher tender joint counts, DAPSA, cDAPSA, SDAI, CDAI and DAS28 than men at baseline
- Despite higher mean baseline CRP, men more often achieved remission, regardless of definition
Original publication
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