Systemic sclerosis & Raynaud's
Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray
Authors' conclusion
This study indicated that serum calcitonin and SOST levels may be promising biomarkers for SSc-related PAH and ILD, respectively.
Study context
- Population
- Systemic sclerosis (SSc) patients with different pulmonary complications
- Comparison
- SSc pulmonary complication subgroups vs SSc without pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD)
- Outcome
- Serum biomarkers for detecting mild, early-stage SSc pulmonary complications (PAH, ILD)
Methodological detailsproteomic antibody microarray (1000 proteins), ELISA verification, correlation analysis with clinical data
- Proteomic antibody microarray (1000 proteins)
- ELISA verification
- Correlation analysis with clinical data
Main finding
As reported in the abstract
Serum biomarkers
- Differentially expressed proteins identified
- 125
Further findings
Associations with organ involvement
- Serum SOST positively related to cardiac and gastrointestinal involvement
- Serum CD40 and calcitonin appeared positively related to renal involvement
- Serum calcitonin positively related to gastrointestinal involvement
Original publication
Protein profiling in systemic sclerosis patients with different pulmonary complications using proteomic antibody microarray. Arthritis Res Ther. Published 17 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →