Systemic sclerosis & Raynaud's
Contribution of Left Ventricular Diastolic Dysfunction to Survival and Breathlessness in Systemic Sclerosis–Associated Interstitial Lung Disease
Authors' conclusion
LVDD in SSc-ILD is more strongly associated with traditional LVDD risk factors than SSc-specific factors. LVDD is associated with worse dyspnea and survival in those with SSc-ILD.
Study context
- Population
- Australian Scleroderma Cohort Study participants with definite systemic sclerosis (SSc) and radiographic interstitial lung disease (ILD)
- Participants
- 102 participants
- Exposure
- SSc-ILD with left ventricular (LV) diastolic dysfunction vs without
- Outcome
- Prevalence of diastolic function categories; mortality with LVDD
Methodological detailslogistic regression, Cox regression
- Logistic regression
- Cox regression
Main finding
As reported in the abstract
Hazard ratio (mortality)
2.4
95% CI 1.0–5.7
P = 0.05
By group
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Severe dyspnoea on Borg Dyspnoea ScaleLVDDvs NormalAdjusted for age and sex | 2.6 (1.0–6.6) | P = 0.05 | |
| WHO Function Class II or higher dyspnoeaLVDDvs NormalAdjusted for age and sex | 4.2 (0.9–20.0) | P = 0.08 | |
| 0.050.21520Odds ratio (log scale) |
Factors associated with LVDD
- Hypertension, OR (P < 0.01)
- 5.0 (95% CI 1.8-13.8)
- Ischemic heart disease, OR (P < 0.01)
- 4.8 (95% CI 1.5-15.7)
- Proximal muscle atrophy, OR (P < 0.01)
- 5.0 (95% CI 1.9-13.6)
- Multimorbidity (Charlson Comorbidity Index ≥ 4), OR (P = 0.04)
- 3.0 (95% CI 1.1-8.7)
- Older age, 95% CI 1.0-6.4; P = 0.05
Original publication
Contribution of Left Ventricular Diastolic Dysfunction to Survival and Breathlessness in Systemic Sclerosis–Associated Interstitial Lung Disease. J Rheumatol. Published 15 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →