PROMIS-29 in rheumatoid arthritis patients who screen positive or negative for fibromyalgia on MDHAQ FAST4 (fibromyalgia assessment screening tool) or 2011 fibromyalgia criteria
Authors' conclusion
Scores for 7 PROMIS-29 domains and MDHAQ were highly correlated. The MDHAQ is effective to assess HRQL and offers incremental medical information, including FAST4 screening.
Study context
- Population
- Rheumatoid arthritis (RA) patients at one routine visit who completed MDHAQ, PROMIS-29 and reference 2011 fibromyalgia (FM) Criteria
- Participants
- 213 patients
- Exposure
- FM+ vs FM- RA patients; RA vs population norms
- Outcome
- PROMIS-29 T-scores in 7 domains (RA vs population norms; FM+ vs FM-) and their association with MDHAQ scores
Methodological detailssingle routine visit
- Single routine visit
Main finding
As reported in the abstract
Median PROMIS-29 T-scores, FM+ vs FM- RA patients
- Clinically and statistically significantly poorer status in 26-29% FM+ vs FM- RA patients, with larger differences than in RA vs population norms for 6/7 domains
Observational data: associations, not effects.
Further findings
Correlation of MDHAQ scores with 7 corresponding PROMIS-29 domains (Spearman)
- |rho|
- ≥0.62
- P
- P < 0.001
Linear regressions, variance explained
- PROMIS-29 T-score variation explained by MDHAQ scores
- 55-73%
- MDHAQ score variation explained by PROMIS-29 T-scores
- 56%-70%
Original publication
PROMIS-29 in rheumatoid arthritis patients who screen positive or negative for fibromyalgia on MDHAQ FAST4 (fibromyalgia assessment screening tool) or 2011 fibromyalgia criteria. Semin Arthritis Rheum. Published 18 January 2024. doi:10.
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