Progression from seropositive arthralgia to rheumatoid arthritis: One-year predictors from a large cohort in the Reuma-Check program
Main finding · Predictor of RA progression in SA (multivariate)Result — go to the resultOdds ratio 7.7 95% CI 1.2–60Authors' conclusion
In the Reuma-Check cohort, among individuals with seropositive arthralgia, ACPA positivity is the most robust predictor of progression to rheumatoid arthritis at 1 year.
Study context
- Population
- Patients in Reuma-Check, a structured diagnostic program for early rheumatologic assessment in Argentina
- Participants
- 1,730 patients
- Exposure
- Seropositive arthralgia vs rheumatoid arthritis (RA); predictors of progression to RA
- Seropositive arthralgia (SA)n = 208
- RAn = 225reference
- Outcome
- Predictors of progression from SA to RA
- Follow-up
- 1 year
Methodological detailslogistic regression
- Logistic regression
Main finding
Predictor of RA progression in SA (multivariate)
Odds ratio
7.7
95% CI 1.2–60
ACPA positivity
OR 7.7 (95% CI 1.2–60)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Prevalence of SA and RA in cohort · baseline
Outcome of SA at 1 year
- Progressed to RA
- 21%
- Developed other immune-mediated conditions
- 14%
- Remained stable
- 65%
Baseline features, SA vs RA
- SA had fewer tender and swollen joints, lower inflammatory markers, and less Power Doppler positivity on US than RA
Original publication
Progression from seropositive arthralgia to rheumatoid arthritis: One-year predictors from a large cohort in the Reuma-Check program. Semin Arthritis Rheum. Published 17 November 2025. doi:10.
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