Vasculitis & polymyalgia rheumatica
Prognostic significance of tubulointerstitial macrophage density in MPO-ANCA-associated glomerulonephritis: implications for renal outcomes
Authors' conclusion
The results of our study provide insight into the prognostic significance of macrophage infiltration in the tubulointerstitium in MPO-ANCA-associated GN.
Study context
- Population
- Patients with MPO-ANCA-associated GN who had renal biopsies at Jinling Hospital (median age 50 y, 43.6% male)
- Participants
- 172 stratified into tertiles
- Exposure
- Tertiles of tubulointerstitial CD68+ macrophage density
- Outcome
- Renal outcomes (renal survival)
Methodological detailssingle-centre, tertiles of tubulointerstitial macrophage density, Kaplan-Meier curves, multivariate Cox proportional hazards regression
- Single-centre
- Tertiles of tubulointerstitial macrophage density
- Kaplan-Meier curves
- Multivariate Cox proportional hazards regression
Main finding
As reported in the abstract
Renal survival
- Lower tubulointerstitial CD68+ macrophage density: significantly better renal survival than higher density (KM curves)
- Higher CD68+ macrophage infiltration significantly associated with adverse renal outcomes, persisting after adjustment for baseline serum creatinine, histopathological class and induction therapy
Observational data: associations, not effects.
Further findings
Differences between the three tertiles
- Significant differences in serum creatinine, induction treatment regimen, rates of end-stage kidney disease and renal histologic class between the three groups
Correlates of tubulointerstitial macrophage density
- Induction treatment regimen and renal histologic class correlated with tubulointerstitial macrophage density
Original publication
Prognostic significance of tubulointerstitial macrophage density in MPO-ANCA-associated glomerulonephritis: implications for renal outcomes. Rheumatology (Oxford). Published 16 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →