Vasculitis & polymyalgia rheumatica
Long-term outcome and clinicopathological characteristics of propylthiouracil-induced anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis: a case-control study
Authors' conclusion
Patients with PTU-induced AAGN demonstrated distinct clinical features and more favourable renal outcomes despite persistent positivity of MPO-ANCA, indicating a less aggressive disease course compared to primary AAGN.
Study context
- Population
- Patients with ANCA-associated glomerulonephritis (AAGN) who underwent diagnostic renal biopsies at Jinling Hospital, January 2005–December 2020
- Participants
- 25 vs 379
- Comparison
- Propylthiouracil (PTU)-induced AAGN vs primary AAGN
- PTU-induced AAGNn = 25
- Primary AAGNn = 379reference
- Outcome
- Long-term renal outcomes (renal survival)
Methodological detailssingle-centre, renal biopsy-based
- Single-centre
- Renal biopsy-based
Main finding
As reported in the abstract
Renal survival (Kaplan-Meier)
- PTU-induced AAGN vs Primary AAGN: P = 0.018
Observational data: associations, not effects.
Further findings
Clinical features at baseline
- Lower serum creatinine and higher MPO-ANCA titres in PTU-induced vs primary AAGN
Histopathology
- Crescentic and focal lesions predominant in PTU-induced group, with higher proportion of normal glomeruli and lower percentage of global sclerosis
Renal non-remission and relapse
- Numerically lower, though statistically non-significant, rates in PTU-induced AAGN; treatment regimens comparable
MPO-ANCA positivity during follow-up · prolonged follow-up
- Serum MPO-ANCA positivity persisted in most PTU-induced AAGN patients
Original publication
Long-term outcome and clinicopathological characteristics of propylthiouracil-induced ANCA-associated glomerulonephritis: a case-control study. Clin Exp Rheumatol. Published 24 June 2025. doi:10.
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