Primary headaches in juvenile-onset systemic lupus erythematosus: A preliminary case control study using ICHD-3 criteria
Authors' conclusion
Primary headaches, particularly migraine, are more frequent in pediatric lupus compared to healthy controls.
Study context
- Population
- Children with juvenile-onset SLE and age- and sex-matched healthy controls, evaluated July–September 2025
- Participants
- 32 vs 38
- Exposure
- jSLE vs age- and sex-matched healthy controls
- jSLEn = 32
- Healthy controlsn = 38reference
- Outcome
- Prevalence of primary headache classified by ICHD-3 criteria
Methodological detailscase-control, age- and sex-matched, preliminary
- Case-control
- Age- and sex-matched
- Preliminary
Main finding
As reported in the abstract
Primary headache (ICHD-3)
P = 0.03
Observational data: associations, not effects.
Further findings
Headache subtypes among jSLE patients with headache
- Migraine without aura
- 60%
- Tension-type headache
- 40%
Factors in jSLE with vs without headache
- Higher BMI z-scores with headache
- P = 0.03
- Shorter sleep duration with headache
- P = 0.03
- More frequent aPL positivity with headache
- P = 0.04
- Higher cumulative corticosteroid doses with headache
- P = 0.02
- Disease activity and duration did not differ significantly
Original publication
Primary headaches in juvenile-onset systemic lupus erythematosus: A preliminary case control study using ICHD-3 criteria. Lupus. Published 20 April 2026. doi:10.
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