Lupus & antiphospholipid syndrome
Prevalence of cognitive impairment and cognitive improvement in patients with systemic lupus erythematosus during a 6-month follow-up study
Authors' conclusion
Mild cognitive impairment is prevalent among patients with SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), April 2021 to March 2022 (median age 44 years; 96% female)173 completed 6-month re-evaluation
- Participants
- 200 patients
- Outcome
- Prevalence of cognitive impairment (Montreal Cognitive Assessment (MoCA); for Thais, 17-24 mild, ≤16 severe) and cognitive changes after 6 months
- Follow-up
- 6 months
Methodological details6-month follow-up, multivariate analysis
- 6-month follow-up
- Multivariate analysis
Main finding
As reported in the abstract
Cognitive impairment (MoCA) at baseline
Cognitive impairment
70%
Mild cognitive impairment
63%
Severe cognitive impairment
7%
Observational data: associations, not effects.
Further findings
Factors associated with cognitive impairment
| OR (95% CI) | ||
|---|---|---|
| Age > 40 yearsMultivariate analysis | 3.71 (1.72–8.00) | |
| Formal education < 12 yearsMultivariate analysis | 3.11 (1.45–6.63) | |
| Prednisolone useMultivariate analysis | 2.21 (1.08–4.51) | |
| 0.10.31310Odds ratio (log scale) |
Most often affected domains · baseline
- Delayed recall
- 82%
- Abstraction
- 80.5%
- Language
- 76%
- Visuospatial/executive function
- 70.5%
- Orientation and naming least involved
Cognitive changes at 6-month re-evaluation (173 patients)
- Any cognitive change
- 66 (38.2%)
- Improved
- 52 [30.1%]
- Deteriorated
- 14 [8.1%]
- All commonly affected domains except delayed recall significantly improved
- Disease activity, prednisolone, antimalarial or immunosuppressant use did not predict cognitive improvement
Original publication
Prevalence of cognitive impairment and cognitive improvement in patients with systemic lupus erythematosus during a 6-month follow-up study. Lupus. Published 17 August 2023. doi:10.
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