Lupus & antiphospholipid syndrome
Prevalence, clinical features, and possible associated factors of mesenteric vasculitis occurrence in patients with systemic lupus erythematosus: An age-, year-at systemic lupus erythematosus (SLE) diagnosis, and disease duration-controlled study
Authors' conclusion
LMV is a rare manifestation in SLE. Active disease, particularly in the renal and hematologic systems, was common prior to LMV onset.
Study context
- Population
- Thai SLE patients in a lupus cohortlupus cohort
- Participants
- 1,538 patients
- Comparison
- SLE patients with lupus mesenteric vasculitis (LMV) vs matched SLE controls without LMV
- LMVn = 31
- Outcome
- Prevalence of LMV
Methodological detailsmatched by age, year at SLE diagnosis and disease duration, cases:controls = 1:2
- Matched by age, year at SLE diagnosis and disease duration
- Cases:controls = 1:2
Main finding
As reported in the abstract
LMV
2.2%
34
Observational data: associations, not effects.
Further findings
Clinical features of LMV episodes
- Nausea, vomiting and diarrhea
- 61.5%-69.2%
- Abdominal pain
- All of the patients
- Diffuse abdominal pain
- 64.1%
- Signs of peritoneal irritation
- 12.8%-15.4%
- Small bowel and colon were common sites involved
- All episodes responded well to corticosteroids and immunosuppressive drugs
Factors at LMV onset vs controls
- LMV patients had more active renal, mucocutaneous and hematologic disease
- Higher degree of proteinuria and SLE disease activity (mSLEDAI-2K score) in LMV
- LMV patients received less prednisolone and fewer immunosuppressive drugs, but a higher daily prednisolone dose
Factors 3 months prior to LMV onset vs controls
- LMV group more anemic and had higher proteinuria
- LMV patients received fewer immunosuppressive drugs, but a higher daily prednisolone dose
Original publication
Prevalence, clinical features, and possible associated factors of mesenteric vasculitis occurrence in patients with systemic lupus erythematosus: An age-, year-at SLE diagnosis, and disease duration-controlled study. Lupus. Published 23 May 2025. doi:10.
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