Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
Authors' conclusion
We found an estimated age-adjusted prevalence of RA and RAILD by analysing real-world data through NLP. RAILD patients were more vulnerable at the time of inclusion with higher comorbidity and inflammatory burden than RAnonILD, which correlated with higher mortality.
Study context
- Population
- Adult patients with rheumatoid arthritis (RA) from nine hospitals in Spain, 2014–2019; source population of 3,176,165 patients and 64,241,683 electronic health records (EHRs)patients with RA
- Participants
- 13,958 patients
- Comparison
- RA with interstitial lung disease (ILD) vs RA without ILD
- Outcome
- Prevalence of RA and RAILD
Methodological detailsobservational, multicentre, natural language processing of EHR
- Observational
- Multicentre
- Natural language processing of EHR
Main finding
As reported in the abstract
Age-adjusted prevalence
Overall age-adjusted prevalence of RA
0.53%
Overall age-adjusted prevalence of RAILD
0.02%
Proportion of RA patients with ILD (RAILD)
5.1%
Observational data: associations, not effects.
Further findings
Infections
P < 0.001
Malignancies
P < 0.001
CVD
P < 0.001
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Death (in-hospital mortality) | 2.32 (1.59–2.81) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Most common ILD subtype: usual interstitial pneumonia
- Usual interstitial pneumonia
- 29.3%
Age, comorbidities and inflammatory burden
- RAILD patients were older, had more comorbidities, more pharmacological prescriptions and higher inflammatory parameters than RAnonILD
Original publication
Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning. RMD Open. Published 30 January 2024. doi:10.
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