Systemic sclerosis & Raynaud's
Prevalence and clinical associations of age-related clonal hematopoiesis in systemic sclerosis
Authors' conclusion
The prevalence of ARCH and CHIP was 32.7% and 23.5%, respectively, in our cohort of patients with SSc presence of ARCH was associated with more severe pulmonary involvement, a higher frequency of pulmonary hypertension, valvular heart disease and ACAs. After adjustment to age and sex, ARCH was associated with a higher NT-pro BNP levels.
Study context
- Population
- Patients with SSc and age- and gender-matched individuals without SSc referred for next-generation sequencing (NGS) without a final diagnosis myelodysplastic syndrome
- Participants
- 196 vs 392
- Comparison
- Prevalence of age-related clonal haematopoiesis (ARCH) in patients with SSc vs age- and gender-matched individuals without SSc; association of ARCH with disease characteristics among patients with SSc
- SScn = 196
- CONTROLn = 392
- Outcome
- Prevalence of ARCH (VAF ≥ 0.8%)
Methodological detailstargeted myeloid next-generation sequencing (NGS)
- Targeted myeloid next-generation sequencing (NGS)
Main finding
As reported in the abstract
P = 0.25
Observational data: associations, not effects.
Further findings
Prevalence of CHIP (ARCH with VAF ≥2%) · similar
P = 0.15
Among patients with SSc: ARCH and NT-proBNP levels
- ARCH associated with higher NT-proBNP levels; after adjustment to age and gender, only NT-proBNP levels remain significantly higher in SSc patients with ARCH
Among patients with SSc: progressive interstitial lung disease, ARCH vs no ARCH
- Higher prevalence with ARCH (unadjusted)
- 39.1% vs 15.7%, P = 0.026
- Not significant after adjustment to age and gender
Among patients with SSc: pulmonary hypertension, ARCH vs no ARCH
- Higher prevalence with ARCH (unadjusted)
- 23.4% vs 11.4%, P = 0.028
- Not significant after adjustment to age and gender
Among patients with SSc: valvular heart disease, ARCH vs no ARCH
- Higher prevalence with ARCH (unadjusted)
- 23.4% vs 11.4%, P = 0.028
- Not significant after adjustment to age and gender
Among patients with SSc: ACAs, ARCH vs no ARCH
- Higher prevalence with ARCH (unadjusted)
- 65.1% vs 49.6%, P = 0.043
- Not significant after adjustment to age and gender
Among patients with SSc: Clonal haematopoiesis of indeterminate potential (CHIP) and disease characteristics
- Associations not observed when restricting to CHIP except for valvular heart disease
- 26.1% vs 11.4%, P = 0.019
- And higher NT-proBNP levels
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →