Spondyloarthritis & psoriatic arthritis
Preterm birth in women with psoriatic arthritis: what are the risks and risk factors? A collaborative cohort study from Sweden, Denmark and Norway
Main finding · Preterm birthResult — go to the resultAdjusted odds ratio 1.80 95% CI 1.29–2.51Authors' conclusion
We identified an 80% increased risk of preterm birth in PsA pregnancies compared with control pregnancies. Antirheumatic combination therapy during and high disease load before pregnancy constituted risk factors. Discontinuing bDMARD treatment in early pregnancy further increased the risk.
Study context
- Population
- Pregnancies in women with psoriatic arthritis (PsA) and matched control pregnancies, clinical rheumatology and medical birth registers in Sweden, Denmark and Norway, 2006–2021matched cohort
- Participants
- 688 vs 6,880
- Exposure
- PsA pregnancies vs matched control pregnancies
- PsAn = 688
- Controln = 6,880reference
- Outcome
- Preterm birth
Methodological detailsmatched 1:10 on age, parity, country and birth year, register linkage, multinational (Sweden, Denmark, Norway)
- Matched 1:10 on age, parity, country and birth year
- Register linkage
- Multinational (Sweden, Denmark, Norway)
Main finding
As reported in the abstract
Adjusted odds ratio
1.80
95% CI 1.29–2.51
Events by group
PsAvs Control
aOR 1.80 (95% CI 1.29–2.51)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (CI) | |
|---|---|---|
| Preterm birth, PsA pregnancies exposed to combination of bDMARD and csDMARD and/or GC during pregnancy (subgroup) | 4.44 (2.07–9.50) | |
| Preterm birth, PsA pregnancies exposed to bDMARD monotherapy (primarily TNFi) (subgroup) | 0.73 (0.22–2.42) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Proportion of preterm birth by bDMARD stopping vs continuing · based on few events
Preterm birth by disease load before pregnancy
- High disease load before pregnancy associated with increased risk
Original publication
Preterm birth in women with psoriatic arthritis: what are the risks and risk factors? A collaborative cohort study from Sweden, Denmark and Norway. RMD Open. Published 5 October 2025. doi:10.
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