Spondyloarthritis & psoriatic arthritis
Prescription of non-steroidal anti-inflammatory drugs for patients with inflammatory arthritis decreases with the initiation of tumour necrosis factor inhibitor therapy: results from the ICEBIO registry
Main finding · NSAID use, DDD per yearResult — go to the resultTimes more DDD 6.7Authors' conclusion
Patients with inflammatory arthritides requiring TNFi therapy use more NSAIDs than matched comparators, and consumption decreased following TNF initiation. Patient-reported measures are not associated with high NSAID use in patients with peripheral arthritis.
Study context
- Population
- Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) in Iceland, 2 years before to 2 years after initiation of a first TNFimatched cohort
- Exposure
- Patients with inflammatory arthritis initiating a first TNFi vs matched general-population comparators; NSAID use before vs after TNFi initiation
- Outcome
- NSAID use (filled prescriptions, DDD per year)
- Follow-up
- 2 years before to 2 years after TNFi initiation
Methodological detailsnationwide, matched comparators (5 per patient, on age, sex and calendar time)
- Nationwide
- Matched comparators (5 per patient, on age, sex and calendar time)
Main finding
NSAID use, DDD per year
Times more DDD
6.7
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| NSAID use after TNFi initiation | Patients mean 85 DDD per year |
| axSpA: highest NSAID-use quintile vs other patients, pain (mm), at TNFi initiation (subgroup)Significantly worse | Highest NSAID quintile mean 66 (SD 21) mm · Other patients mean 60 (SD 23) mm |
| axSpA: highest NSAID-use quintile vs other patients, global health (mm), at TNFi initiation (subgroup)Significantly worse | Highest NSAID quintile mean 70 (SD 20) mm · Other patients mean 64 (SD 23) mm |
| axSpA: highest NSAID-use quintile vs other patients, HAQ score, at TNFi initiation (subgroup)Significantly worse | Highest NSAID quintile mean 1.21 (SD 0.66) · Other patients mean 1.02 (SD 0.66) |
- NSAID use after TNFi initiation — Decrease in RA
- 42%
- NSAID use after TNFi initiation — Decrease in PsA
- 43%
- NSAID use after TNFi initiation — Decrease in axSpA
- 48%
Peripheral arthritis: highest NSAID-use quintile vs other patients (subgroup) · TNFi initiation
- No significant differences observed in the groups with peripheral arthritis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prescription of non-steroidal anti-inflammatory drugs for patients with inflammatory arthritis decreases with the initiation of tumour necrosis factor inhibitor therapy: results from the ICEBIO registry. Scand J Rheumatol. Published 4 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →