Spondyloarthritis & psoriatic arthritis
Exploration of the combined role of immune checkpoints and immune cells in the diagnosis and treatment of ankylosing spondylitis: a preliminary study immune checkpoints in ankylosing spondylitis
Authors' conclusion
Immune checkpoints and immune cells could serve as avenues for exploring diagnostic and therapeutic strategies for AS.
Study context
- Population
- Patients undergoing hip arthroplasty (hip ligament samples); peripheral blood data of 104 ankylosing spondylitis (AS) patients from a public database104 AS patients (public blood data)
- Comparison
- AS with femoral head deformity vs femoral head necrosis without AS
- Outcome
- Expression of immune checkpoint proteins HLA-DMB and HLA-DPA1 in hip ligaments, AS vs femoral head necrosis without AS (LFQ proteomics, validated in peripheral blood datasets and IHC); immune cell infiltration and its prediction of AS
Methodological detailsproteomic (Label-Free Quantification (LFQ)) analysis of hip ligaments, validation in public peripheral blood dataset, immunohistochemistry (IHC) validation
- Proteomic (LFQ) analysis of hip ligaments
- Validation in public peripheral blood dataset
- IHC validation
Main finding
As reported in the abstract
AUC of LASSO-selected immune cell prediction models for AS
0.98, 0.81, and 0.75
Original publication
Exploration of the combined role of immune checkpoints and immune cells in the diagnosis and treatment of ankylosing spondylitis: a preliminary study immune checkpoints in ankylosing spondylitis. Arthritis Res Ther. Published 4 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →