Lupus & antiphospholipid syndrome
Pregnancy Outcomes in Patients With Interstitial Lung Disease
Authors' conclusion
Although APOs were common in women with very severe ILD and underlying CTD, overall maternal morbidity and mortality were low.
Study context
- Population
- Pregnancies in patients with interstitial lung disease (ILD) with underlying autoimmune disease, Duke University Health System; 85% Black, 71% sarcoidosis, 29% CTD-ILDpregnancies in 60 women
- Participants
- 86 pregnancies
- Exposure
- Pregnancies by ILD severity on pulmonary function tests (PFTs) and by underlying disease
- Outcome
- Adverse pregnancy outcomes (APOs) defined by PROMISSE-APO and Severe PROMISSE-APO criteria
Methodological detailssingle health system (Duke University Health System), medical record review
- Single health system (Duke University Health System)
- Medical record review
Main finding
As reported in the abstract
PROMISSE-APOs
Very severe ILD
all pregnancies
CTD-ILD
56%
Sarcoidosis
23%
Very severe ILD: P = 0.02 across severity groups · CTD-ILD vs Sarcoidosis: P = 0.02
- PROMISSE-APOs, all pregnancies
- 32%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Severe PROMISSE-APOs | Very severe ILD 60% · CTD-ILD 28% |
| ILD severity among pregnancies with available PFTs (n = 59) | Very severe ILD 12% · Severe ILD 25% · Mild-moderate ILD 51% · Normal lung function 12% |
- Severe PROMISSE-APOs — Severe PROMISSE-APOs, all pregnancies
- 15%
Maternal morbidity and mortality
- Maternal deaths
- 0
- ICU stay during pregnancy
- 1
- Volume overload after delivery, resolved with medical management
- 3
- Oxygen during delivery
- 7
- Intubated
- 0
Original publication
Pregnancy Outcomes in Patients With Interstitial Lung Disease. Arthritis Care Res (Hoboken). Published 4 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →