Lupus & antiphospholipid syndrome
Pregnancy characteristics of patients with systemic lupus erythematosus with different onset times and their risk of adverse pregnancy outcomes: a retrospective cohort study
Authors' conclusion
Patients with SLE onset in adulthood during pregnancy exhibit more aggressive disease manifestations and higher rates of APOs, while women with childhood-onset or pre-pregnancy-onset SLE had a lower risk.
Study context
- Population
- Pregnant women with SLE admitted to Nanfang Hospital of Southern Medical University, 2010–2024
- Participants
- 223 women251 pregnancies
- Exposure
- SLE onset in adulthood during pregnancy vs childhood onset vs onset in adulthood before pregnancy
- Outcome
- Adverse pregnancy outcomes (APOs) by onset time of SLE
Methodological detailssingle-centre, logistic regression
- Single-centre
- Logistic regression
Main finding
As reported in the abstract
APOs by SLE onset time
Fetal loss, onset in adulthood during pregnancy: OR
5.342
95% CI 1.629 to 17.520p=0.006
Premature birth, onset in adulthood during pregnancy: OR
6.390
95% CI 1.244 to 32.828p=0.026
Observational data: associations, not effects.
Original publication
Pregnancy characteristics of patients with systemic lupus erythematosus with different onset times and their risk of adverse pregnancy outcomes: a retrospective cohort study. Lupus Sci Med. Published 3 June 2025. doi:10.
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