Lupus & antiphospholipid syndrome
A retrospective study of long-term outcomes related with initial factors in childhood onset systemic lupus erythematosus
Authors' conclusion
Initial SLEDAI-2K and bio-markers for immune response were related to survival and events during follow-up.
Study context
- Population
- Patients diagnosed with childhood onset SLE (cSLE) at <18 years, January 2009 to December 2021; excluding prior diagnoses, transfers, infection- or post-transplantation-related findings and underlying diseasesfemale to male ratio 7.4:1
- Participants
- 109 patients
- Outcome
- Factors at diagnosis associated with long-term outcomes: survival and events (flare, complications, new organ involvement)
Methodological detailsreview of electronic medical records, univariate and multivariate analysis
- Review of electronic medical records
- Univariate and multivariate analysis
Main finding
As reported in the abstract
Survival and events
- Overall survival rate (median: 5.0 years)
- 92.9 %
- Survival: elevated C-reactive protein (CRP), multivariate HR 2.396 (95% CI 1.165 ∼4.926)
- p = .017
- Event free survival
- 10.4%
- Event: SLEDAI-2K, multivariate HR 2.82 (95% CI 1.078∼7.375)
- p = .035
- Event: anti-Smith antibody, multivariate HR 3.262 (95% CI 1.218∼8.741)
- p = .019
Observational data: associations, not effects.
Further findings
Univariate associations
- Survival associated with CRP, SLEDAI-2K and false positivity for syphilis
- P < 0.05
- Event free survival related to SLEDAI-2K, anti-Smith antibody and false positivity for syphilis
- P < 0.05
- Univariate analysis
Baseline characteristics
- Mean age, years (± 2.3)
- 14.4
- Diagnosed pre-pubertal, n = 28
- 25.7%
Causes of death
- Intractable macrophage activation syndrome, n
- 2
- Disease related state, n
- 2
- Infection, n
- 2
Original publication
A retrospective study of long-term outcomes related with initial factors in childhood onset systemic lupus erythematosus. Lupus. Published 30 May 2025. doi:10.
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