Predictors of thrombotic events in patients with idiopathic inflammatory myopathies
Authors' conclusion
We report the incidence and risk factors for thrombotic events in a single-centre longitudinal IIM cohort, showing early occurrence of VTE and late onset of ATE. PON1 activity was predictive of ATE in a high-risk subgroup of IIM patients.
Study context
- Population
- Patients with idiopathic inflammatory myopathies (IIM) in a large longitudinal cohort followed at a single academic centre
- Participants
- 312 patients
- Outcome
- Predictors of prospective arterial and venous thrombotic events (ATE and VTE)
Methodological detailssingle-centre, longitudinal cohort, Poisson regression
- Single-centre
- Longitudinal cohort
- Poisson regression
Main finding
As reported in the abstract
median [IQR] follow-up 6[2-11] years
- Thrombotic events
- 37 out of 312 patients (12%)
- VTE among patients with thrombotic events (predominantly within first 3 years of IIM diagnosis)
- 65%
- ATE among patients with thrombotic events (predominantly after 10 years from IIM diagnosis)
- 41%
- Disease duration <1 year, strongest risk factor for VTE: IRR
- 6.49 (1.89-22.35) (95% CI)
- Prior ATE, strongest risk factor for prospective ATE: IRR
- 18.78 (10.98-32.12) (95% CI)
Observational data: associations, not effects.
Further findings
- PON1 lactonase activity independent of PON1 Q192R polymorphism; enhanced prediction of ATE in patients with high cardiovascular (CV) risk
Safety
- IVIG not associated with increased thrombotic risk in a high-risk population
Original publication
Predictors of thrombotic events in patients with idiopathic inflammatory myopathies. Clin Exp Rheumatol. Published 25 November 2024. doi:10.
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