Vasculitis & polymyalgia rheumatica
Predictors of relapse, early escalation and 1-Year use of glucocorticoids in new-onset polymyalgia rheumatica: A prospective cohort study
Authors' conclusion
Monitoring of treatment response within the first one week after diagnosis may help identify patients requiring early glucocorticoid escalation and those at risk of a more severe disease trajectory and may be part of individualized management of PMR.
Study context
- Population
- Newly diagnosed PMR patients, diagnosis confirmed after 1 year of follow-upconfirmed PMR at 1 year
- Participants
- 60 participants
- Exposure
- CRP baseline vs CRP week 1
- Outcome
- Need for glucocorticoid (GC) escalation to achieve remission between week 2 and week 4; relapse between week 10 and 1 year; ongoing prednisolone at 1 year
Methodological detailsprediction models with ROC-curve cut-off estimation
- Prediction models with ROC-curve cut-off estimation
Main finding
As reported in the abstract
Early prednisolone escalation: CRP cut-offs · week 2 to week 4
| Group | Cut-off | Sensitivity | Specificity |
|---|---|---|---|
| CRP baseline | 41.5mg/L | 78% | 73% |
| CRP week 1 | 22.5mg/L | 88% | 94% |
Cut-off
CRP baseline41.5mg/L
CRP week 122.5mg/L
Sensitivity
CRP baseline78%
CRP week 188%
Specificity
CRP baseline73%
CRP week 194%
Observational data: associations, not effects.
Further findings
Relapse: CRP cut-offs · week 10 to 1 year
Cut-off CRP baseline 49.5mg/L · CRP week 1 7.5mg/L
Sensitivity
Specificity
Refractory disease within 4 weeks as predictor of relapse
| OR (95% CI) | ||
|---|---|---|
| Refractory disease within 4 weeks | 3.7 (1.01–10.58) | |
| 0.050.21520Odds ratio (log scale) |
Refractory disease within 4 weeks as predictor of ongoing prednisolone at 1 year
| OR (95% CI) | ||
|---|---|---|
| Refractory disease within 4 weeks | 4.84 (1.51–15.5) | |
| 0.050.21520Odds ratio (log scale) |
Ongoing prednisolone at 1 year
- Similar results as relapse
Original publication
Predictors of relapse, early escalation and 1-Year use of glucocorticoids in new-onset polymyalgia rheumatica: A prospective cohort study. Semin Arthritis Rheum. Published 1 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →