Vasculitis & polymyalgia rheumatica
Plasma proteome differences between giant cell arteritis and polymyalgia rheumatica: a pilot study
Authors' conclusion
Active PMR and active GCA patients share an unexpectedly small plasma proteome signature related to immune activation (8.9%: 13 proteins). Instead, active PMR is characterized by distinct erythrocyte and muscle contraction proteome changes, whereas active GCA appears driven by mitochondrial and clotting cascade alterations.
Study context
- Population
- Patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA)
- Participants
- 15 vs 13
- Comparison
- Plasma proteome of active PMR vs active GCA
- PMRn = 15
- GCAn = 13
- Outcome
- Altered plasma protein signatures
Methodological detailspilot study, mass spectrometry plasma proteomics, immunofluorescence of temporal artery biopsy (TABs)
- Pilot study
- Mass spectrometry plasma proteomics
- Immunofluorescence of TABs
Main finding
As reported in the abstract
Protein signatures characteristic of active GCA
50
Signatures altered only in active PMR
83
Proteins with altered expression shared by both groups
13
S100A12 increased in plasma (also in PMR and GCA TABs)
≈1.6-fold
Original publication
Plasma proteome differences between giant cell arteritis and polymyalgia rheumatica: a pilot study. Arthritis Res Ther. Published 1 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →