Predictors of Placebo Response to Local (Intra‐Articular) Therapy In Osteoarthritis: An Individual Participant Data Meta‐Analysis
Authors' conclusion
The administration of local anesthetics or ultrasound guidance may reduce IA placebo response at short-term follow-up. At midterm follow-up, participants with worse baseline function scores may be less likely to respond to IA placebo, and mid- to long-term trial duration may enhance the placebo response.
Study context
- Population
- Placebo participants in randomized placebo-controlled trials of intra-articular (IA) GC or hyaluronic acid for knee/hip osteoarthritis (OA), published to September 2018
- Participants
- 621 participants10 studies
- Outcome
- Placebo response, defined as at least a 20% reduction in baseline pain
Methodological detailsrandom effects model, logistic regression, generalized mixed-effect models
- Random effects model
- Logistic regression
- Generalized mixed-effect models
Pooled result
As reported in the abstract
Predictors of placebo response
- Short-term follow-up: local anesthetic use associated with reduced odds of placebo response
- Short-term follow-up: US guidance associated with reduced odds of placebo response
- Midterm follow-up: mid- to long-term trial duration associated with increased odds of placebo response
- Midterm follow-up: worse baseline function scores associated with reduced odds of placebo response
Original publication
Predictors of Placebo Response to Local (Intra‐Articular) Therapy In Osteoarthritis: An Individual Participant Data Meta‐Analysis. Arthritis Care Res (Hoboken). Published 25 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →